The primary bioactive compound in Spilanthes acmella is spilanthol. Spilanthol, an alkamide is responsible for the benefits of the ingredient. Spilanthol is known to activate a specific ion channel in sensory neurons called TRPA1 (Transient Receptor Potential Ankyrin 1). TRPA1 activation is associated with the sensation of pain, leading to a numbing or tingling sensation when activated. The sensation can enhance sensitivity and pleasure during sexual activity.

Studies suggest that Spilanthes acmella may stimulate the release of luteinizing hormone (LH). LH plays a crucial role in the regulation of testosterone production in the testes. Increased LH levels can lead to an increase in testosterone synthesis.

Spilanthes acmella has adaptogen properties, which may help the body adapt to stress and restore balance. Chronic stress can negatively impact testosterone levels, so by promoting overall well-being and reducing stress, Spilanthes acmella can have positive effects on sexual function and performance.

Traditional uses of Spilanthes acmella include its reputation as an aphrodisiac. While the mechanisms are not fully understood, it is thought to potentially influence hormonal levels and sexual desire.